Basal Cell Carcinoma with Disseminated Bone Metastization: An Unusual Outcome of the Most Common Malignancy

Basal cell carcinoma is the most common skin cancer, with a very low incidence of metastases, associated high morbidity and mortality. The morpheaform clinical variant uncommon, presenting an aggressive growth pattern. Early diagnosis new targeted therapies for metastatic disease are important to improve survival rates. We present case 29-year-old patient basal in right genian region. Due local recurrences, he underwent surgery adjuvant radiotherapy. For extensive bone involvement, started vismodegib and, later, pembrolizumab, also performed palliative Despite several lines systemic therapy, progressed, died after 8 years follow-up. This shows how crucial it identify risk factors highlights need target tailor them patient’s biological profile.